It is believed that many forms of chronic or long-term depression are caused by brain chemistry that is not functioning properly enough. For example, some types of depression are associated with low levels of brain chemicals, such as dopamine and serotonin. Nicotine can cause the brain to release these chemicals, so the smoker "feels good." Thus, someone who is depressed may feel better temporarily when smoking. This also means that when it comes to quitting smoking, the symptoms of depression can actually get worse - since you are no longer going to get those extra doses of dopamine and serotonin.
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